Identification of CD137 as a potent monocyte survival factor.
نویسندگان
چکیده
CD137 (ILA/4-1BB), a member of the tumor necrosis factor (TNF) receptor family, promotes adherence and prolongs survival of human peripheral monocytes. It induces a strong expression of macrophage colony-stimulating factor (M-CSF), an essential monocyte survival factor. Monocyte survival induced by CD137 is primarily mediated by M-CSF and to a lesser extent by granulocyte-macrophage colony-stimulating factor and IL-3. Survival and induction of M-CSF are mediated via reverse signaling through a CD137 ligand expressed constitutively by peripheral monocytes.
منابع مشابه
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ورودعنوان ژورنال:
- Journal of leukocyte biology
دوره 65 6 شماره
صفحات -
تاریخ انتشار 1999